First and foremost, good quality, unbalanced cables are a must.
Next, you are working with Line Output voltage, which is just 2-volts peak to peak. In some instances, it may be as low as 1.2 volts. Keep in mind, though, that this is a constant, and usually not controlled by your master volume control.
In most instances, where there is a noise problem, it is usually associated with either the wrong cables being used, or outside interference from an associated device that is connected to the keyboard.
To determine the noise source, unplug everything from the keyboard, foot pedals, mic, etc... Now, connect your mixer to the line out of the keyboard. If the noise is no longer present, the next step is to connect the associated devices, mic, foot pedals, etc..., one at a time and the noise returns, then you'll know the source.
If the noise is still there, there could be a problem with a poorly grounded power cord, or fluorescent, overhead lights, which is not at all uncommon.
Finally, be sure that all devices are properly grounded to the same AC system. Best to use a quality power strip, one that has a ground fault indicator, which will tell you if the ground connection if poor or non existent.
Personally, I never used the line out of my arranger keyboards, and because of all the built in features, was able to completely eliminate a mixer from my setup. It was just something that could easily go wrong during the middle of a performance.
Hope this helps,
Gary