I use the Focusrite Scarlett 8i6 v3 with my Genos and Yamaha HS7 speakers. It sounds fantastic, coming from an older Focusrite Saffire Pro 24 DSP the definition, sound stage and overall quality of the Scarlett is very noticeable. I'm using it with a Mac via USB-C and also have my Yamaha analog mixer and a Audio Technica AT2035 mic with it. Software wise though I'm using Logic Pro X. I did a lot of research and decided bang for buck the Scarlett 8i6 latest model was the best available in terms of reputation, quality, flexibility with it's combination of SPDIF, Optical and Analog inputs, 2 headphone sockets, the AIR option on mics and lots of free plugins and goodies included.
Simon