Hi Gary,
I have all my Registrations in Folders like Fifties, Sixties, Beatles, America, Moody Blues, etc... all stored in the USER Section. These all point to Styles and Midi's also stored in the USER sections. From these I make a Playlist depending on the audience I am playing for hypothetically, because I don't gig. There is no lag when switching from one Registration/song to another. The only time there would be any wait, was if someone requests a song that is not in the Playlist. If you are storing everything on USB, there would be some delay as USB is not as fast as the USER section. As Fred Stated above, be sure to backup. I too was working off off USB sticks, and foolishly not back up thinking USB's never fail, but they do. USER drive is the best place to work out of and then back up to a USB and if you have a computer, make a copy of this on the PC as well. Also be sure to back up the Genos System settings periodically too.
Rick D.