Hi Depo1964,
if you use Vocal Harmony and/or other effects (e. g. Reverb/Delay) on the microphone from Genos, I recommend to use TWO (2) sub outputs for the genos mic signal (and go in STEREO to your external mixer).
If you don't use effects from Genos, it is sufficient to use only ONE sub out for the mic (and go only in MONO to the mixer). Alternatively, you can of course connect your mic directly to the mixer (and use its mic effects).
If you connect your mic directly to the mixer, you can still use the Vocal Harmony and/or other effects of the Genos: To do this you have to route the mic signal to an AUX SEND (output) at the external mixer and connect this signal to the Mic Input of the Genos. Then be sure that the mic is routed to TWO (2) sub outputs and only the EFFECT signal(s) are audible on these sub outs. For this, you have to set the "Balance" parameter in Vocal Harmony display to "L>H63".
Best regards,
Chris