Hi Michael
I use my Yamaha DXR8 On main out and that goes though a hum destroyer in between Genos and speakers.
They are quite a powerful pair ,but excellent quality down at the right levels
I then plug in the SPDF cable and route that to my Focusrite 6i6 and same as your diagram the USB on the Focusrite 6i6 goes to computer and back to the Focusrite and out the RCA's to my Focal Alpha 50's
Well that seems to be the right set up plugged up wise.
Update
I have got it all working.
I had to get logical
I sat at the machine and slowly had another set up go and got it right.
Played an orchestral sound and it recorded at 20 Luf's straight off, so that is in the ballpark for Cubase mixing.
It is on things like tambourines that need bumping up but as things like that are just enhancements to a song 30 Luf should be alright or even normalize low sounds like maraccas etc.
So now i can leave my DXR 8's in the main out and SPDF takes care of the recording and playback.
The only thing now is to get my vst instruments to play on the Genos.
I have one pair of AKG headphones on the Genos and a pair in the Focusrite 6i6 and my Focal Alpha monitors from the Focusrite RCA outs .
What i want now is to get the VST sound on the DXR 8's for my live practice and fun.
I realize that the VST's will not come back down the SPDF cable into the Genos .
Will i have to use my spare focusrite out 1 an 2 sockets with RCA leads to the Genos AUX in ?
At the moment i cannot get a receive instrument audio.
I have Arturia VST 's and Korg plus Sampletank and i have all the Arturia and Korg synths as standalones as well as for Cubase and all running at buffer size 256 smoothly at 5 ms latency. Not bad that.
I like to say to everyone it is best to get a fast music computer purpose built with a 32gig drive.
Computer side of things are no worries especially with system images made. Always keep two on separate terrabyte drives.
This saves all the heartaches of losing everything
All the best
John