I am having a similar issue. After 2 years of so, the usb connection from Genos to computer, loses contact. It usually works fine on start up, but at some point, momentarily loses contact. The computer issues a warning, and will not work until you hit ok, and then fiddle with cable. Often I have to restart Kenos, I have to jiggle it to get it back. I take a small sliver of paper hold it against usb plug. That tightens the contact, and makes more solid.
25 years ago, computer manufactures used 'military spec' jacks and plugs. (guaranteed to be exactly the right size) they switched to cheaper hardware, so as a result, some jacks, plugs, are ever to slightly larger, smaller. I've had this happen to two macs, since the 90's (new computer every 3 years).
You might try a different usb cable, or do the sliver of paper thing. Mine has become quite bad now, every 2 - 6 hours, it looses connection. A disaster if you were performing live.