Yes, it takes some time, but most people adjust to it quite fast. I've played 61 key devices for more than 20 years, but when I played a 76 key T5 in the shop, a was amazed by the extra possibilities, and bought it. Eventually it took me less than a week to totally adjust. I dropped the idea of positioning my hands relative to the top or bottom of the keys and instead always work from the central C1. After enough practising, your brains and muscle memory adjust perfectly and you position your hands without thinking.